Ofloxacin + Ornidazole + Itraconazole + Clobetasol is a combination of four medicines: Ofloxacin , Ornidazole , Itraconazole and Clobetasol. Ofloxacin is an antibiotic that kills bacteria by preventing them from reproducing and repairing themselves. Ornidazole is also an antibiotic that kills other infectious microorganisms in addition to bacteria by damaging the DNA. Itraconazole is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection. Clobetasol is a steroid medicine. It blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen and itchy.